This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union.

This Regulation shall be binding in its entirety and directly applicable in all Member States.

Done at Brussels, 11 May 2023.

For the Commission

The President

Ursula VON DER LEYEN

( 1 ) OJ L 327, 11.12.2015, p. 1 .

( 2 ) Commission Implementing Regulation (EU) 2017/2470 of 20 December 2017 establishing the Union list of novel foods in accordance with Regulation (EU) 2015/2283 of the European Parliament and of the Council on novel foods ( OJ L 351, 30.12.2017, p. 72 ).

( 3 ) Directive 2002/46/EC of the European Parliament and of the Council of 10 June 2002 on the approximation of the laws of the Member States relating to food supplements ( OJ L 183, 12.7.2002, p. 51 ).

( 4 ) 2.2 Identity Cellobiose UPDATED 07122021.pdf; 2.2.1 ID_NMR_Cellobiose.pdf; 2.2.2 ID_NMR_Cellobiose_Amendment.pdf; 2.2.6 Cellobiose_NMR-Data_UPDATED_07052021.pdf; 2.2.7 Cellobiose_HRMS-Data_UPDATED_07122021.pdf; 2.2.10_Cellobiose NMR HMBC COS UPDATED 07122021.pdf

( 5 ) 2.3.15 PCR Enzyme_1_UPDATED_07052021.pdf; 2.3.16 PCR Enzyme_2_UPDATED_07052021.pdf

( 6 ) 2.4.3.2 Stab cellob applications.pdf; 2.4.01 Comp Anal. L1018025.pdf; 2.4.02 Comp Anal. L1018031.pdf; 2.4.03 Comp Anal. L1018205.pdf; 2.4.04 Comp Anal. L1018231.pdf; 2.4.05 Comp Anal. L1017514.pdf; 2.4.06 DNA_Cellobiose.pdf; 2.4.07 Stability analysis L1018025_UPDATED_07122021.pdf; 2.4.08 Stability analysis L1018031_UPDATED_07122021.pdf; 2.4.09 Stability analysis L1018205_UPDATED_07122021.pdf; 2.4.10 Stability analysis L1018231_UPDATED_07122021.pdf; 2.4.11 Stability analysis L1017514_UPDATED_07122021.pdf; 2.4.12_Summary stability UPDATED 07122021.xlsx; 2.4.13 Cellobiose applications food; 2.4.14 VA CRO Val.pdf; 2.4.29_LoD protein-content_NEW 06122021.pdf

( 7 ) 2.10.2.1 Genotoxicity.pdf; 2.10.2.1.1 OECD 471 Cellobiose.pdf; 2.10.2.1.2 OECD 487 Cellobiose.pdf

( 8 ) 2.10.2.3 Subchronic oral toxicity UPDATED_07052021.pdf; 2.10.2.3.1 Dose_Range_Cellobiose.pdf; 2.10.2.3.2 OECD 408 Cellobiose.pdf; 2.10.2.3.3._32942_Suppl_2021-05-03.pdf

( 9 ) 2.10.3 Human data.pdf; 2.10.3.3.1 Tolerance Cellobiose final.pdf; 2.10.3.3.2 Study protocol.pdf; 2.10.3.3.3 Study protocol Signatures.pdf; 2.10.3.3.4 Statist analysis plan signed.pdf; 2.10.3.3.5 Statistical analysis.pdf; 2.10.3.3.6 Data listing.pdf; Moré, Postrach, Bothe, Heinritz and Uebelhack (2019). A Dose-Escalation Study Demonstrates the Safety and Tolerability of Cellobiose in Healthy Subjects. Nutrients 12(1): 64, https://www.mdpi.com/2072-6643/12/1/64.

( 10 ) EFSA Journal 2022;20(11):7596.

( 11 ) Dürener Straße 67, 50189 Elsdorf, Germany.

COMMISSION IMPLEMENTING REGULATION (EU) 2023/943 of 11 May 2023 authorising the placing on the market of cellobiose as a novel food and amending Implementing Regulation (EU) 2017/2470 ANNEX