This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union .

This Regulation shall be binding in its entirety and directly applicable in all Member States.

Done at Brussels, 3 June 2025.

For the Commission

The President

Ursula VON DER LEYEN

( 1 ) OJ L 152, 16.6.2009, p. 11 , ELI: http://data.europa.eu/eli/reg/2009/470/oj .

( 2 ) Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin ( OJ L 15, 20.1.2010, p. 1 , ELI: http://data.europa.eu/eli/reg/2010/37(1)/oj ).

( 3 ) Commission Regulation (EU) 2018/782 of 29 May 2018 establishing the methodological principles for the risk assessment and risk management recommendations referred to in Regulation (EC) No 470/2009 ( OJ L 132, 30.5.2018, p. 5 , ELI: http://data.europa.eu/eli/reg/2018/782/oj ).

( 4 ) Chemical-unlike biological substances considered as not requiring an MRL evaluation as per Regulation (EU) 2018/782, with regard to residues of veterinary medicinal products in foodstuffs of animal origin of 20 November 2023, EMA/CVMP/572629/2019–Rev.2, Committee for Veterinary Medicinal Products of European Medicines Agency.

( 5 ) Commission Regulation (EU) 2025/1101 of 3 June 2025 amending Regulation (EU) 2018/782 concerning the assessment by the European Medicines Agency of maximum residue limits for chemical-unlike biological substances ( OJ L 2025/1101, 4.6.2025 , ELI: http://data.europa.eu/eli/ reg/2025/1101/oj ).

( 6 ) Scientific advice on MRL classification of chemical-unlike biological substances considered as not requiring an MRL evaluation according to Regulation (EU) 2018/782. EMA/CVMP/375793/2024.

COMMISSION IMPLEMENTING REGULATION (EU) 2025/1102 of 3 June 2025 amending Regulation (EU) No 37/2010 as regards chemical-unlike biological substances ANNEX