This Regulation shall enter into force on the twentieth day following that of its publication in the Official Journal of the European Union .

This Regulation shall be binding in its entirety and directly applicable in all Member States.

Done at Brussels, 4 November 2025.

For the Commission

The President

Ursula VON DER LEYEN

( 1 ) OJ L 404, 30.12.2006, p. 9 , ELI: http://data.europa.eu/eli/reg/2006/1924/oj .

( 2 ) EFSA NDA Panel (EFSA Panel on Nutrition, Novel Foods and Food allergens), Turck, D., Bresson, J. L., Burlingame, B., Dean, T., Fairweather-Tait, S., Heinonen, M., Hirsch-Ernst, K. I., Mangelsdorf, I., McArdle, H. J., Naska, A., Neuhäuser-Berthold, M., Nowicka, G., Pentieva, K., Sanz, Y., Sjödin, A., Stern, M., Tomé, D., Van Loveren, H., Siani, A. (2018). Guidance for the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health: (revision 1). EFSA Journal , 16(1), e05136. https://doi.org/10. 2903/j.efsa.2018. 5136 .

( 3 ) Mayoral, P., Martinez-Salgado, C. S., Santiago, J. M., Rodriguez-Hernandez, M. V., García-Gomez, M. L., Morales, A., López-Novoa, J. M., & Macías-Nuñez, J. F. (2003). Effect of ham protein substitution on oxidative stress in older adults. The Journal of Nutrition, Health & Aging, 7, 84–89.

( 4 ) EFSA Journal . 2024;22(7):e8862.

COMMISSION REGULATION (EU) 2025/2222 of 4 November 2025 refusing to authorise a health claim made on foods and referring to the reduction of disease risk ANNEX Rejected health claim